Examinations
Examinations
Creatinine is the final product of creatine phosphate metabolism, which is involved in the energy exchange of muscles and other tissues. Creatinine synthesis occurs predominantly in muscle tissue. During muscle contraction, creatine phosphate breaks down, forming creatine.
Due to greater muscle mass, creatinine levels in men are higher than in women. Creatinine is filtered in the kidney glomeruli, not reabsorbed, and not secreted in the tubules. Therefore, an increase in creatinine levels typically indicates a decrease in glomerular filtration and renal excretory function.
- The test is performed on a blood sample drawn from a vein.
- Fasting for 8-14 hours is required before the test.
- The test can be taken 4 hours after a light meal.
- Avoid emotional and physical stress, as well as alcohol, prior to the test.
- Kidney function evaluation.
- Diseases of striated (skeletal) muscles.
- Acute and chronic kidney failure.
- Acromegaly and gigantism.
- Radiation sickness.
- Hyperthyroidism.
- Dehydration.
- High intake of meat products.
- Use of nephrotoxic drugs.
Decreased Creatinine Levels:
- Fasting or muscle mass loss.
- Corticosteroid use.
- Pregnancy (especially in the first and second trimesters).
- Vegetarian diet.
- Muscular dystrophy.