Examinations
Examinations
Paracetamol/acetaminophen is one of the most common and widely used analgesics in the world. It is the drug of choice within non-steroidal anti-inflammatory formulations for patients with bronchial asthma, peptic ulcer disease, hemophilia, as well as for children, pregnant, and lactating women. Paracetamol is well tolerated and, when dosed properly, causes few gastrointestinal side effects; however, the number of cases of liver damage due to paracetamol ingestion continues to increase worldwide each year.
Paracetamol is a medication with analgesic, antipyretic, and mild anti-inflammatory properties. Its mechanism of action is associated with the inhibition of prostaglandin synthesis, primarily by reducing the activity of the thermoregulatory center in the hypothalamus. Treatment with paracetamol is effective, well tolerated by most patients, and safe when used at therapeutic doses. However, even at therapeutic doses, paracetamol can cause serious liver damage in susceptible individuals, in people who consume alcohol, or when used in combination with other medications.
- Biomaterial for the study: venous blood.
- Do not consume any food for 12 hours before the test.
- 24 hours before the test, you should stop taking medications (with the consent of your treating physician).
- Determination of the drug's toxicity level.
- Monitoring the concentration of paracetamol in the blood.
Results of the study are evaluated by the attending physician, taking into account the drug dosage, method of administration, patient’s age, comorbidities, and individual tolerance to the medication.
After a single 500 mg dose, the maximum plasma concentration is reached within 10–60 minutes and is approximately 6 µg/ml, then it gradually decreases, and after 6 hours it is 11–12 µg/ml.