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Duloxetine

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According to scientific hypotheses, depressive disorders arise from a deficiency of noradrenaline and/or serotonin in certain brain structures. To treat these pathological conditions, "mood-enhancing" medications—known as timoleptics—are used.

Duloxetine is an antidepressant (timoleptic) that inhibits the reuptake of neurotransmitters (serotonin and noradrenaline) at synapses, thereby enhancing serotonergic and noradrenergic neurotransmission in the nervous system. The drug is effective in treating severe depression with melancholic features, as well as mild depressive disorders. The timoleptic effect develops very quickly—within the first week of use. Duloxetine also exerts analgesic effects; it influences the central mechanism of pain suppression and increases the pain threshold in neuropathic pain syndromes. In many countries worldwide, duloxetine is used in the treatment of fibromyalgia—a syndrome of chronic musculoskeletal pain of unclear etiology in the absence of significant organic or autoimmune pathology.

  • Biomaterial for the study: venous blood.
  • Do not consume any food for 2–3 hours before the test.
  • Stop taking medications 24 hours before the test (with the consent of your treating physician).
  • When prescribing duloxetine along with other medications (including those related to certain diseases and conditions);
  • when monitoring patients with impaired liver or kidney function, as well as pregnant women taking duloxetine (in these cases, if the benefit of the medication outweighs the potential risk);
  • when addressing insufficient efficacy of the current medication and adjusting the dose;
  • if there is suspicion that the patient is not adhering to the prescribed regimen;
  • and when there is suspicion of duloxetine overdose (characterized by vomiting, loss of appetite, tremor, clonic seizures, and ataxia).

Substances that increase the concentration of duloxetine in the blood include fluvoxamine, desipramine, tolterodine, caffeine, and others. Taking medications that are metabolized in the liver, that bind extensively to blood proteins, and that affect kidney function can influence the level of duloxetine in the blood. Additionally, in cases of liver and kidney failure, the concentration of the drug in the blood increases.