Examinations
Examinations
Cancer remains one of the most prevalent diseases worldwide, with malignant tumors being a leading cause of death. Currently, over 14 million people are battling cancer.
The earlier a malignant tumor is detected, the better the treatment outcomes. Tumor markers are used for the early detection of cancer susceptibility or direct cancer diagnosis.
What is the ROMA Index?
The ROMA Index (Risk of Ovarian Malignancy Algorithm) is one of the key methods for assessing women's health, specifically for detecting pathological processes in the ovaries. Ovarian cancer is one of the most common malignant tumors in women, and the ROMA Index helps identify epithelial ovarian cancer.
Additionally, this test can serve as a supplementary diagnostic tool for:
- Pancreatic cancer
- Breast cancer
- Cervical cancer
- Lung cancer
How is the ROMA Index Calculated?
The ROMA Index is calculated using a specific mathematical formula, which requires measuring the levels of two tumor markers:
- HE4 (Human Epididymis Protein 4)
- CA 125 (Cancer Antigen 125)
Results vary depending on the menopausal status of the patient (premenopause or postmenopause).
- Sample: Blood drawn from a vein.
- The test can be taken at least 4 hours after a light meal.
- Before testing, patients should avoid physical and emotional stress and alcohol consumption.
Women at risk of developing ovarian cancer (e.g., family history, lifestyle factors, pelvic organ diseases) are advised to take the ROMA tumor marker test once a year.
Accuracy of the ROMA Algorithm
- Postmenopausal women:
- Sensitivity: 92.3%
- Specificity: 76.0%
- Premenopausal women:
- Sensitivity: 100%
- Specificity: 74.2%
- Overall accuracy in all women:
- Sensitivity: 93.8%
- Specificity: 74.9%
- Negative predictive value: 99%
Additionally, the ROMA algorithm detects:
- 94% of women with invasive ovarian cancer
- 85% of women with early-stage ovarian cancer