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Beta-Cross Laps (Beta-CTx)

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Beta-Cross Laps (Beta-CTx) is a collagen-related fragment of Type I collagen, specifically indicating bone resorption. It reflects the breakdown of Type I collagen in bones and is widely used for assessing bone turnover.

Clinical Significance of Beta-CTx

  • Beta-CTx levels show strong circadian fluctuations, so blood samples should be taken before 9:00 AM after overnight fasting.
  • It is more reliable than urinary bone markers, as urine collection can introduce errors due to preservation, dilution issues, and creatinine correction inaccuracies (which depend on muscle mass and kidney function).

Biomaterial: Venous blood
Pre-test recommendations:

  • Fasting for 12 hours before the test.
  • Discontinue medications 24 hours before testing (with physician approval).
  • Diagnosis of osteoporosis
  • Monitoring and evaluating osteoporosis treatment effectiveness
  • Decision-making and monitoring of hormone replacement therapy (HRT) in postmenopausal women
  • Chronic kidney disease (CKD) assessment

Causes of Increased Beta-CTx Levels

  • Hyperparathyroidism
  • Osteoporosis
  • Paget’s disease
  • Menopause
  • Rheumatoid arthritis
  • Renal failure