Sərbəst testosteron

25 Azn

Free testosterone is the biologically active fraction of testosterone that is not bound to blood proteins.

  • Testosterone has anabolic effects on muscle tissue, supports bone development, regulates sebaceous gland activity, and participates in the synthesis of liver lipoproteins.
  • It modulates the synthesis of β-endorphins and insulin.
  • In men, testosterone plays a key role in the psychophysiological aspects of the reproductive system, secondary sexual characteristics, libido, spermatogenesis, potency, and sexual behavior.
  • In women, testosterone is involved in follicular regression in the ovaries and regulates gonadotropic hormone levels from the pituitary gland.

    Why Measure Free Testosterone?

  • Free testosterone levels are independent of sex hormone-binding globulin (SHBG).
  • Therefore, measuring free testosterone is more informative than total testosterone, especially when SHBG levels are altered.
  • The analysis is performed on a blood sample drawn from a vein.
  • Stop eating8–14 hours before the test.
  • Before the test, avoid:
    • Emotional and physical stress
    • Alcohol consumption
  • Discontinue estrogen and androgen medications48 hours before testing.
  • Unless otherwise directed by a doctor, the test should be performed before 11:00 AM.

For Both Men and Women:

  • Infertility
  • Hair loss
  • Acne
  • Oily seborrhea
  • Aplastic anemia
  • Adrenal tumors
  • Monitoring during glucocorticoid and androgen therapy

For Women:

  • Hirsutism
  • Anovulation
  • Amenorrhea
  • Oligomenorrhea
  • Dysfunctional uterine bleeding
  • Miscarriages
  • Polycystic ovary syndrome (PCOS)
  • Androgenital syndrome
  • Uterine fibroids
  • Endometriosis
  • Breast tumors
  • Uterine and breast hypoplasia

For Men:

  • Erectile dysfunction
  • Decreased libido
  • Male menopause (andropause)
  • Primary and secondary hypogonadism
  • Chronic prostatitis
  • Osteoporosis

Causes of Increased Free Testosterone Levels

  • Cushing's disease and syndrome
  • Androgenital syndrome (in women)
  • Testosterone-producing testicular tumors
  • XYY karyotype (47, XYY syndrome)
  • Ovarian tumors

    Causes of Decreased Free Testosterone Levels

  • Adrenal insufficiency
  • Hypogonadism
  • Chronic prostatitis
  • Obesity
  • Genetic disorders of sexual development