Progesteron

25 Azn

Progesterone is a steroid hormone produced by the corpus luteum of the ovaries. It is essential for the normal progression of pregnancy.

  • Progesterone is synthesized in the ovaries and, in small amounts, in the adrenal glands, under the influence of luteinizing hormone (LH).
  • During the first and early second trimester of pregnancy, progesterone is primarily produced by the maternal body.
  • From the late second trimester onward, progesterone production shifts to the placenta.
     

    Functions of Progesterone

  • Prepares the endometrium for the implantation of a fertilized egg.
  • Supports pregnancy after implantation.
  • During pregnancy, progesterone levels rise continuously, doubling by weeks 7–8 and gradually increasing until weeks 37–38.
  • Outside of pregnancy, progesterone levels begin to rise in the preovulatory phase, peak in the mid-luteal phase, and return to baseline at the end of the cycle.

     
  • The analysis is performed on a blood sample drawn from a vein.
  • The test should be taken after 8–14 hours of fasting.
  • Before the test, avoid emotional and physical stress, as well as alcohol consumption.
  • If no specific timing is prescribed, women with menstrual cycles should take the test on days 22–23 of the cycle.
  • Investigation of menstrual cycle disorders and various forms of amenorrhea
  • Infertility assessment
  • Dysfunctional uterine bleeding
  • Evaluation of placental function in the second trimester of pregnancy

Causes of Increased Progesterone Levels

  • Dysfunctional uterine bleeding
  • Certain types of secondary amenorrhea
  • Fetoplacental dysfunction
  • Delayed fetal maturation
  • Impaired progesterone metabolism in kidney failure

Medications That Increase Progesterone Levels:

  • Clomiphene
  • Corticotropin
  • Ketoconazole
  • Mifepristone
  • Valproic acid
  • Tamoxifen
     

    Causes of Decreased Progesterone Levels

  • Chronic inflammation of the internal reproductive organs
  • Anovulatory dysfunctional uterine bleeding
  • Various forms of primary and secondary amenorrhea
  • Placental underdevelopment
  • Intrauterine growth restriction (IUGR)
  • Medications That Decrease Progesterone Levels:

  • Ampicillin
  • Carbamazepine
  • Cyproterone
  • Danazol
  • Epistan
  • Estriol
  • Pravastatin