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β-2-qlikoprotein 1 IgA

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Beta-2-glycoprotein 1 (β-2-GP1) antibodies are autoantibodies produced in response to blood clotting disorders. They belong to the antiphospholipid antibody group and are associated with conditions affecting vascular health and pregnancy outcomes.

Clinical Significance

  • β-2-GP1 IgA, IgG, and IgM antibodies are tested in relation to antiphospholipid syndrome (APS), cardiolipin antibodies, and lupus anticoagulant tests, as they target the phospholipid layer in erythrocyte membranes.
  • The exact mechanism is not fully understood, but β-2-GP1 antibodies contribute to arterial and venous thrombosis.
  • Common in autoimmune disorders, particularly antiphospholipid syndrome (APS), which leads to:
    • Blood clotting abnormalities
    • Severe thrombocytopenia (low platelet count)
    • Preeclampsia (high blood pressure and protein in urine during pregnancy)
    • Recurrent pregnancy loss (especially in the 1st and 2nd trimesters)
  • IgA subclass testing is recommended when IgG and IgM results are negative, but APS symptoms are present.
  • Take the test at least 2 hours after the last meal.
  • Avoid smoking for 3 hours before the test.
  • Avoid physical and emotional stress for 1 hour before the test.
  • Suspected Antiphospholipid Syndrome (APS)
  • Unexplained venous thrombosis
  • Recurrent pregnancy loss

Interpretation of Results

Positive β-2-GP1 IgA Test May Indicate:

  • Antiphospholipid Syndrome (APS)

Negative β-2-GP1 IgA Test:

  • No evidence of APS or related conditions.

Clinical Importance

  • APS is a serious autoimmune condition that can cause life-threatening blood clots, miscarriages, and pregnancy complications.
  • β-2-GP1 IgA testing is crucial for APS diagnosis, particularly when IgG and IgM results are negative, but clinical symptoms persist.
  • Regular monitoring is necessary for patients with APS, unexplained clotting disorders, or pregnancy complications.

This test plays a key role in diagnosing APS and preventing severe thrombotic and pregnancy-related complications.