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Fosfatidilserin IgM

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Phosphatidylserine (PS) antibodies are autoantibodies associated with antiphospholipid syndrome (APS). Phosphatidylserine is a negatively charged phospholipid found in cell membranes, particularly in platelets and endothelial cells. The formation of anti-phosphatidylserine antibodies is a type of antiphospholipid antibody and is considered a possible cause of APS.

Clinical Significance

  • Antiphospholipid antibodies can alter platelet and endothelial cell function, leading to thrombosis (deep vein thrombosis, stroke).
  • They are detected in autoimmune disorders, including systemic lupus erythematosus (SLE) and APS, but may also be transiently elevated in infections and malignancies.
  • Take the test at least 2 hours after the last meal.
  • Avoid smoking for 3 hours before the test.
  • Avoid physical and emotional stress for 1 hour before the test.
  • Suspected Antiphospholipid Syndrome (APS)
  • Unexplained thrombosis (arterial or venous)
  • Recurrent pregnancy loss
  • Thrombocytopenia (low platelet count)

Positive Anti-Phosphatidylserine IgM Test May Indicate:

  • Antiphospholipid Syndrome (APS) (confirmed with 2 or more positive tests at least 6 weeks apart)
  • Systemic autoimmune diseases (especially SLE)
  • Infectious diseases (e.g., Hepatitis C, malaria, Lyme disease, syphilis, HIV)
  • Drug-induced antibodies
  • Malignancies (cancer, leukemia)
  • Alcoholic liver disease (cirrhosis)

Negative Anti-Phosphatidylserine IgM Test:

  • No evidence of APS or related conditions.