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Anti-ssDNT IgG

24 Azn
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Anti-ssDNA antibodies are autoantibodies that target single-stranded DNA (ssDNA) and are detected using an ELISA-based in-vitro test system. This test is primarily used in serological investigations of lupus and drug-induced urticaria.

Clinical Significance

  • Anti-ssDNA antibodies fluctuate based on disease activity:
    • Detected in 87% of patients during acute lupus flares.
    • Present in 43% of patients during inactive disease phases.
  • Used alongside anti-histone antibodies for the differential diagnosis of drug-induced lupus.
  • Detected in more than 50% of patients with drug-induced lupus.
  • Also associated with collagen vascular diseases and juvenile idiopathic arthritis (JIA).
  • Take the test at least 2 hours after the last meal.
  • Avoid smoking for 1 hour before the test.
  • Avoid physical and emotional stress for 1 hour before the test.
  • Suspected scarlet fever.
  • Suspected drug-induced lupus.

Interpretation of Results

Positive Anti-ssDNA Test May Indicate:

  • Systemic lupus erythematosus (SLE).
  • Drug-induced lupus.

Negative Anti-ssDNA Test:

  • No evidence of systemic or drug-induced lupus.