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Creatine Kinase (CK)

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Creatine kinase (CK) is a diagnostic test used to detect inflammation and damage to muscles. It is commonly applied in the diagnosis of muscle dystrophies and rhabdomyolysis. CK levels are also checked following physical trauma, such as accidents, burns, or other injuries. Additionally, CK serves as a critical indicator in myocardial infarction (heart attack) and myopathies. Elevated CK activity can be observed 4 hours after a heart attack, peaking within 12–24 hours, and typically returning to baseline within 3–4 days.

The CK-MB isoenzyme test is specifically used to determine if damage is occurring in cardiac muscle or skeletal muscles in cases where CK levels are high.

  • Blood is drawn from a vein.
  • The test can be performed 4 hours after a light meal.
  • Avoid physical and emotional stress before the test.
  • Refrain from alcohol consumption.
  • Muscle pain
  • Muscle weakness
  • Dark-colored urine (indicating the presence of myoglobin, a marker of muscle damage)
  • Diagnosis of myocardial infarction
  • Cancer diagnosis
  • Hypothyroidism

Causes of Elevated CK Levels

  • Trauma: Physical injuries causing muscle damage.
  • Myocardial infarction (heart attack): CK levels rise rapidly in heart damage.
  • Muscle ischemia: Impaired blood flow to the muscles.
  • Muscular dystrophies: Various types of muscle degeneration.
  • Central nervous system disorders: Certain neurological conditions.
  • Malignant tumors: Cancer-related muscle or tissue damage.
  • Congestive heart failure: Poor heart function.
  • Tachycardia: Rapid heart rate.
  • Generalized seizures: Widespread muscular contractions.
  • Medications: Corticosteroids, barbiturates, and narcotics.
  • Strenuous physical exercise: Seen in healthy individuals following intense physical activity.