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Natriuretic N-terminal peptide (type B)

55 Azn
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Pro-natriuretic N-terminal peptide B-type (Pro-BNP) is used in the detection and diagnosis of heart failure. Pro-BNP is a peptide synthesized in the heart when it expands and works overtime, pumping blood into the vessels. It is one of the main tests used in cardiology.

Pro-BNP helps doctors differentiate heart failure from other similar conditions, such as lung diseases. Symptoms of heart failure include:

  • Difficulty breathing, shortness of breath
  • Fatigue, depression
  • Swelling of the legs.

Pro-BNP is also used to assess the effectiveness of therapy in patients receiving treatment for heart failure. An elevated level of Pro-BNP almost always indicates heart failure. However, the result may be influenced by the following factors, so they should be considered individually:

  • Kidney dysfunction
  • Patient's age and gender. NT-proBNP levels may be higher in women.
  • Rheumatoid factor
  • Presence of a pacemaker.

The test is performed on a blood sample taken from a vein.
It is recommended to take the test on an empty stomach after 8–14 hours of fasting.
The test can be taken 4 hours after a light meal.
Before the examination, psycho-emotional and physical stress, as well as alcohol consumption, should be avoided.

  • In case of heart failure.
  • In case of acute pain during ischemic heart disease.
  • During simultaneous monitoring of the effectiveness of heart failure treatment.

Levels of N-terminal pro-B-type natriuretic peptide (NT-proBNP) most often indicate heart failure. Conversely, a result below the normal range almost rules out its presence.

Causes of Elevated N-terminal Pro-B-type Natriuretic Peptide (NT-proBNP) Levels:

  • Chronic heart failure: The higher the NT-proBNP level, the more severe the heart failure.
  • Acute increased load on the left ventricle of any origin.
  • Presence of a pacemaker.