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Osteocalcin

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Osteocalcin (GLA protein) is the primary non-collagenous protein in bone tissue, playing a key role in calcium and hydroxyapatite binding. It is synthesized by osteoblasts and odontoblasts and consists of 49 amino acids, with a molecular weight of approximately 5800 Da.

Clinical Significance of Osteocalcin

  • Osteocalcin is a sensitive marker of bone metabolism.
  • Its blood concentration reflects osteoblastic activity, as osteocalcin in the bloodstream results from new synthesis rather than bone resorption.
  • It is believed to play a role in regulating calcium absorption.
  • High osteocalcin levels correlate with increased bone resorption, making it a useful indicator of bone turnover and metabolic bone diseases.

Regulatory Factors

  • Osteocalcin is vitamin K-dependent.
  • Calcium directly influences the synthesis of regulatory hormones, including:
    • Calcitonin
    • Parathyroid hormone (PTH)
    • Vitamin D
    • Other regulatory factors affecting osteoblast activity

Biomaterial: Venous blood
Pre-test recommendations:

  • Fasting for 12 hours before the test
  • Discontinuation of medications 24 hours before the test (under medical supervision)
  • Diagnosis of osteoporosis
  • Monitoring antiresorptive therapy in osteoporosis patients
  • Hypercalcemic syndrome
  • Recommended in combination with deoxypyridinoline (DPD) testing for a more comprehensive assessment of bone metabolism

Artması:

  • postmenopozal osteoporoz;
  • osteomalasiya;
  • Birincil və ikincil hiperparatireoz;
  • Paget xəstəliyi;
  • böyrək osteodistrofiyası;
  • Şişlər, sümük metastazları;
  • Diffuz zəhərli guatr;
  • yeniyetmələrdə sürətli böyümə;
  • Xroniki böyrək çatışmazlığı.

Azalması:

  • Hiperkortizolizm (İtsenko-Cushing xəstəliyi və sindromu);
  • Glukokortikoid hormon terapiyası;
  • hipoparatireoz;
  • Birincili biliyer siroz;
  • Hamiləlik;
  • Böyümə hormonu çatışmazlığı.