Placental Growth Factor (PlGF)

65 Azn

Placental Growth Factor (PlGF) – A Marker for Preeclampsia Risk

Placental Growth Factor (PlGF) is a key biomarker for evaluating the risk of preeclampsia—a serious pregnancy complication.

What is Preeclampsia?

Preeclampsia is a severe pregnancy complication characterized by:

Hypertension (high blood pressure)
Proteinuria (protein in urine)
Usually occurring after the 20th week of pregnancy

Affects 5–10% of pregnancies and can lead to severe maternal and fetal complications or even stillbirth.
PlGF testing helps predict preeclampsia 3–5 weeks before clinical onset, allowing early intervention.

Blood sample from a vein.
No special preparation is required.

Clinical Applications of PlGF Testing

First-Trimester Screening (12–13 Weeks)

Combined with PAPP-A (Pregnancy-Associated Plasma Protein-A)
Helps detect intrauterine growth restriction (IUGR) risk

Second-Trimester Screening (17–21 Weeks)

Assesses placental blood flow
Poor circulation in the placenta can lead to severe fetal complications

Reference Values for PlGF (pg/mL)

Gestational Age	Normal Range (pg/mL)
10–14 weeks	22 – 71.3
15–19 weeks	65.7 – 203
20–23 weeks	125 – 541
24–28 weeks	130 – 1108
29–33 weeks	73.3 – 1108
34–36 weeks	62.7 – 972
37 weeks and beyond	52.3 – 659