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Fosfatidilserin IgG

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Phosphatidylserine (PS) antibodies are autoantibodies associated with antiphospholipid syndrome (APS). Phosphatidylserine is a negatively charged phospholipid found in cell membranes, particularly in platelets and endothelial cells. Anti-phosphatidylserine antibodies belong to the antiphospholipid antibody family and are considered a potential cause of APS.

Clinical Significance

  • Anti-phosphatidylserine IgG antibodies can disrupt platelet function and endothelial integrity, leading to blood clot formation (deep vein thrombosis, stroke).
  • These antibodies are commonly found in patients with autoimmune diseases, particularly APS.
  • APS is associated with:
    • Increased risk of blood clots
    • Thrombocytopenia (low platelet count)
    • Pregnancy complications (miscarriages, preeclampsia, fetal loss)
  • Take the test at least 2 hours after the last meal.
  • Avoid smoking for 3 hours before the test.
  • Avoid physical and emotional stress for 1 hour before the test.
  • Suspected Antiphospholipid Syndrome (APS)
  • Unexplained thrombosis (arterial or venous)
  • Recurrent pregnancy loss
  • Thrombocytopenia

Positive Anti-Phosphatidylserine IgG Test May Indicate:

  • Antiphospholipid Syndrome (APS) (confirmed with two or more positive tests at least 6 weeks apart)
  • Systemic autoimmune diseases (especially systemic lupus erythematosus - SLE)
  • Infectious diseases (e.g., Hepatitis C, malaria, Lyme disease, syphilis, HIV)
  • Drug-induced antibodies
  • Malignancies (cancer, leukemia)
  • Alcoholic liver disease (cirrhosis)

Negative Anti-Phosphatidylserine IgG Test:

  • No evidence of APS or related conditions.